THE EFFECTS OF PGF2-ALPHA ON RESPIRATORY AND CARDIOVASCULAR VARIABLES IN PIG

PGF2α was injected into different parts of the circulatory system (intravenously by femoral and jugular veins,into the pulmonary artery,into the ascending or descending aorta and into the internal carotid artery at a level above the sinus and carotid body) of anaesthetized spontaneously breathing pigs.It caused changes in respiratory and cardiovascular variables.In vagosympathectomized animals the changes in pattern of breathing produced by PGF2 a were greatly reduced and total lung resistance was increased.This may indicates more than one site of action of PGF2α,lung resistance being influenced by a direct action of PGF2α a and by an immediate reflex while the pattern of breathing being modulated by vagaafferents from the lungs. © 1979.