GASTROINTESTINAL EFFECTS OF SINGLE AND REPEATED DOSES OF FERROUS SULFATE IN RATS

被引：25

作者：

BENONI, G ^{[1
]}

CUZZOLIN, L ^{[1
]}

ZAMBRERI, D ^{[1
]}

DONINI, M ^{[1
]}

DELSOLDATO, P ^{[1
]}

CARAMAZZA, I ^{[1
]}

机构：

[1] ITALFARMACO RES CTR,MILAN,ITALY

来源：

PHARMACOLOGICAL RESEARCH | 1993年 / 27卷 / 01期

关键词：

IRON; GASTROENTERIC TRACT; INTESTINAL FLORA; RAT; HISTOPATHOLOGY;

D O I：

10.1006/phrs.1993.1007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The gastrointestinal effects of single and repeated administration of ferrous sulphate was evaluated measuring faecal flora modifications and histology of stomach and duodenum of the rat. The acute experiments showed reversible histopathological lesions of stomach and duodenum with iron deposition and increase in faecal Cl. perfringens toxin after treatment with a high dose of FeSO4. The chronic experiment at lower doses showed no relevant histological damage, some iron deposition and strong alterations in faecal flora. A strong impact of oral FeSO4 on gastrointestinal environment was demonstrated. © 1993 Academic Press. All rights reserved.

引用

页码：73 / 80

页数：8

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