THE 3-WEEK SULFASALAZINE SYNDROME

被引：17

作者：

BROOKS, H ^{[1
]}

TAYLOR, HG ^{[1
]}

NICHOL, FE ^{[1
]}

机构：

[1] LEICESTER ROYAL INFIRM,DEPT RHEUMATOL,LEICESTER LE1 5WW,ENGLAND

来源：

CLINICAL RHEUMATOLOGY | 1992年 / 11卷 / 04期

关键词：

SULFASALAZINE; SERUM SICKNESS; HYPERSENSITIVITY; RHEUMATOID ARTHRITIS; HEPATITIS; ADVERSE DRUG REACTION;

D O I：

10.1007/BF02283121

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We report a 53-year-old man with sero-negative rheumatoid arthritis who developed a fever, rash and hepatitis 3 weeks after starting sulphasalazine therapy. This was associated with a T cell lymphocytosis, eosinophilia and evidence of classical complement pathway activation. He responded to high dose corticosteroids. This is a rare but characteristic reaction which is likely to be encountered by rheumatologists more frequently with the increasing use of sulphasalazine. It should be recognized promptly as it may be fatal and can be confused with other systemic diseases.

引用

页码：566 / 568

页数：3

共 18 条

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