PPL-CATALYZED ENZYMATIC ASYMMETRIZATION OF A 5-SUBSTITUTED PROCHIRAL 1,3-DIOL WITH REMOTE CHIRAL FUNCTIONALITY - IMPROVEMENTS TOWARD SYNTHESIS OF THE EUTOMERS OF SCH-45012

被引：17

作者：

LOVEY, RG

SAKSENA, AK

GIRIJAVALLABHAN, VM

机构：

[1] Schering-Plough Research Institute, Kenilworth, NJ 07033

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 33期

关键词：

D O I：

10.1016/0040-4039(94)88071-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Porcine pancreatic lipase (PPL) catalysis has been used to establish both stereocenters of the cis-(tetrahydrofuranylmethy) tosylate 4. In addition to the enzymatic differentiation of the hydroxyl groups of the pro-chiral 1,3-diol segment of 2, successful enzymatic resolution of the racemic diol 10 provided an alternate route to the important precursor 1.

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页码：6047 / 6050

页数：4

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