A NEW METHOD FOR THE RESOLUTION OF AMINES AND ITS APPLICATION TO 3-AMINO-1,5-BENZODIAZEPINES

被引：12

作者：

CUROTTO, G

DONATI, D

FINIZIA, G

URSINI, A

机构：

[1] Glaxo Research Laboratories, 37153 Verona

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 04期

关键词：

D O I：

10.1016/0957-4166(95)00086-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new method for the resolution of racemic amines and its application to 3-amino-1,5-benzodiazepines is reported. The method is based upon the reaction of the amines with a chiral auxiliary, namely the tosyl derivative of (S)-(+)-methyl mandelate, followed by the separation of the two diastereomers formed and the subsequent hydrogenation of the separated compounds to give the free chiral amines with good enantiomeric excesses.

引用

页码：849 / 852

页数：4

共 7 条

[1]

FINCH H, 1993, Patent No. 9314074

[2]

GASC JC, 1991, Patent No. 376849

[3] STERICALLY CONTROLLED SYNTHESES OF OPTICALLY-ACTIVE ORGANIC-COMPOUNDS .26. TEMPERATURE-DEPENDENCE OF HYDROGENOLYTIC ASYMMETRIC TRANSAMINATION BETWEEN ESTERS OF OPTICALLY-ACTIVE PHENYLGLYCINE AND PYRUVIC-ACID [J].