REDUCTION OF HYPERLIPIDEMIA IN HEPATOMA-BEARING RATS BY DIETARY FISH-OIL

被引：22

作者：

KAWASAKI, M ^{[1
]}

YAGASAKI, K ^{[1
]}

MIURA, Y ^{[1
]}

FUNABIKI, R ^{[1
]}

机构：

[1] TOKYO NOKO UNIV,DEPT APPL BIOL SCI,FUCHU,TOKYO 183,JAPAN

来源：

LIPIDS | 1995年 / 30卷 / 05期

关键词：

D O I：

10.1007/BF02536301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of dietary fish oil on serum lipid levels was studied by comparing it with dietary corn oil in Donryu rats subcutaneously implanted with an ascites hepatoma cell line (AH109A). The hepatoma-bearing rats exhibited hyperlipidemia charactarized by a rise in both serum cholesterol and triglyceride levels. Increased cholesterogenesis in the host liver and decreased steroid excretion into feces are suggested to be responsible for the hepatoma-induced hypercholesterolemia, and increased fatty acid mobilization from peripheral adipose tissues and decreased triglyceride clearance from the blood circulation are considered causes for the hepatoma-induced hypertriglyceridemia. Dietary fish oil reduced the hyperlipidemia in these animals, suppressed the hepatoma-induced increase in hepatic cholesterogenesis and fatty acid mobilization from adipose tissue. Dietary fish oil also tended to increase fatty acid oxidation in the liver. Such diverse effects of fish oil may lead to the reduction of the hepatoma-induced hyperlipidemia. These results suggest that studies on dietary fish oil may be warranted in patients with cancer-related hyperlipidemia.

引用

页码：431 / 436

页数：6

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