INTRATHYMIC AND EXTRATHYMIC CLONAL DELETION OF T-CELLS

被引：173

作者：

SPRENT, J

WEBB, SR

机构：

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 02期

关键词：

D O I：

10.1016/0952-7915(95)80004-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clonal elimination accounts for self-tolerance induction in the thymus and also affects mature T cells responding to exogenous antigens in the periphery. Recent evidence on the microenvironments, cell-cell interactions and signalling requirements for clonal deletion of immature and mature T cells is discussed.

引用

收藏

页码：196 / 205

页数：10

相关论文

共 118 条

[1]

AIBA Y, 1994, INT IMMUNOL, V6, P1475

[2] THE SPECIFIC RECOGNITION BY MACROPHAGES OF CD8(+),CD45RO(+) T-CELLS UNDERGOING APOPTOSIS - A MECHANISM FOR T-CELL CLEARANCE DURING RESOLUTION OF VIRAL-INFECTIONS [J].

AKBAR, AN ;

SAVILL, J ;

GOMBERT, W ;

BOFILL, M ;

BORTHWICK, NJ ;

WHITELAW, F ;

GRUNDY, J ;

JANOSSY, G ;

SALMON, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (05) :1943-1947

[3] A POSSIBLE ROLE FOR BCL-2 IN REGULATING T-CELL MEMORY - A BALANCING ACT BETWEEN CELL-DEATH AND SURVIVAL [J].

AKBAR, AN ;

SALMON, M ;

SAVILL, J ;

JANOSSY, G .

IMMUNOLOGY TODAY, 1993, 14 (11) :526-532

[4] FAS TRANSDUCES ACTIVATION SIGNALS IN NORMAL HUMAN T-LYMPHOCYTES [J].

ALDERSON, MR ;

ARMITAGE, RJ ;

MARASKOVSKY, E ;

TOUGH, TW ;

ROUX, E ;

SCHOOLEY, K ;

RAMSDELL, F ;

LYNCH, DH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :2231-2235

[5] IMMATURE THYMOCYTES BECOME SENSITIVE TO CALCIUM-MEDIATED APOPTOSIS WITH THE ONSET OF CD8, CD4, AND THE T-CELL RECEPTOR EXPRESSION - A ROLE FOR BCL-2 [J].

ANDJELIC, S ;

JAIN, N ;

NIKOLICZUGIC, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (05) :1745-1751

[6] THE ONSET OF FAS EXPRESSION PARALLELS THE ACQUISITION OF CD8 AND CD4 IN FETAL AND ADULT ALPHA-BETA THYMOCYTES [J].

ANDJELIC, S ;

DRAPPA, J ;

LACY, E ;

ELKON, KB ;

NIKOLICZUGIC, J .

INTERNATIONAL IMMUNOLOGY, 1994, 6 (01) :73-79

[7] CYTOTOXICITY OF FRESH NK1.1(+) T-CELL RECEPTOR ALPHA/BETA(+) THYMOCYTES AGAINST A CD4+8+ THYMOCYTE POPULATION ASSOCIATED WITH INTACT FAS ANTIGEN EXPRESSION ON THE TARGET [J].

ARASE, H ;

ARASE, N ;

KOBAYASHI, Y ;

NISHIMURA, Y ;

YONEHARA, S ;

ONOE, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (02) :423-432

[8] A DIFFERENTIAL-AVIDITY MODEL FOR T-CELL SELECTION [J].

ASHTONRICKARDT, PG ;

TONEGAWA, S .

IMMUNOLOGY TODAY, 1994, 15 (08) :362-366

[9] PEPTIDE CONTRIBUTES TO THE SPECIFICITY OF POSITIVE SELECTION OF CD8+ T-CELLS IN THE THYMUS [J].

ASHTONRICKARDT, PG ;

VANKAER, L ;

SCHUMACHER, TNM ;

PLOEGH, HL ;

TONEGAWA, S .

CELL, 1993, 73 (05) :1041-1049

[10] THE DEGREE OF CD8 DEPENDENCE OF CYTOLYTIC T-CELL PRECURSORS IS DETERMINED BY THE NATURE OF THE T-CELL RECEPTOR (TCR) AND INFLUENCES NEGATIVE SELECTION IN TCR-TRANSGENIC MICE [J].

AUPHAN, N ;

CURNOW, J ;

GUIMEZANES, A ;

LANGLET, C ;

MALISSEN, B ;

MELLOR, A ;

SCHMITTVERHULST, AM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (07) :1572-1577

← 1 2 3 4 5 6 7 8 9 10 →