2,3-BENZOXAZINES .9. SYNTHESIS AND CENTRAL NERVOUS SYSTEM DEPRESSANT ACTIVITY OF SOME 3,6- AND 3,7-DISUBSTITUTED 1H-3,4-DIHYDRO-2,3-BENZOXAZINES

被引：9

作者：

PIFFERI, G

CONSONNI, P

BANFI, S

DIENA, A

机构：

[1] Research Laboratories, Lepetit S.p.A., Milan

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 02期

关键词：

D O I：

10.1021/jm00302a014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

On the basis of the CNS depressant activity of 3-methyl-1H-3,4-dihydro-2,3-benzoxazine (Ib), a number of 3,6-and 3,7-disubstituted 1H-3,4-dihydro-2,3-benzoxazines were synthesized in order to observe the influence of the substituents on the pharmacological activity. © 1969, American Chemical Society. All rights reserved.

引用

页码：261 / &

共 11 条

[1]

ARNES RA, 1957, J ORG CHEM, V22, P1038

[2]

BIRD RF, 1952, J CHEM SOC, P505

[3]

IRWIN S, 1959, MULTIDIMENSIONAL SCR, P133

[4] THE PREPARATION AND PROPERTIES OF 2-SUBSTITUTED ISOARSINDOLINES AND OF AS-SPIRO-BISISOARSINDOLINIUM SALTS [J].

LYON, DR ;

MANN, FG ;

COOKSON, GH .

JOURNAL OF THE CHEMICAL SOCIETY, 1947, (MAY) :662-670

[5]

PIFFERI G, 1968, FARMACO-ED SCI, V23, P568

[6]

PIFFERI G, 1967, FARM ED PRAT, V22, P210

[7]

PIFFERI G, 1966, GAZZ CHIM ITAL, V96, P1671

[8]

PIFFERI G, IN PRESS

[9]

RANDALL LO, 1957, ARCH INT PHARMACOD T, V111, P409

[10] HYDROXYLAMINE CHEMISTRY .4. O-ARALKYLHYDROXYLAMINES [J].

SCHUMANN, EL ;

VELDKAMP, W ;

GREIG, ME ;

HEINZELMAN, RV .

JOURNAL OF MEDICINAL CHEMISTRY, 1964, 7 (03) :329-&

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