EFFICACY OF ANTI-MICROBIAL THERAPY IN EXPERIMENTAL RAT PNEUMONIA - ANTIBIOTIC-TREATMENT SCHEDULES IN RATS WITH IMPAIRED PHAGOCYTOSIS

被引：8

作者：

BAKKERWOUDENBERG, IAJM ^{[1
]}

VANGERWEN, ALEM ^{[1
]}

MICHEL, MF ^{[1
]}

机构：

[1] ERASMUS UNIV, DEPT CLIN MICROBIOL & ANTIMICROB THERAPY, ROTTERDAM, NETHERLANDS

来源：

INFECTION AND IMMUNITY | 1979年 / 25卷 / 01期

关键词：

D O I：

10.1128/IAI.25.1.376-387.1979

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pneumococcal pneumonia in rats with intact host defense mechanisms could be successfully cured by penicillin. The efficacy of this antibiotic therapy was lost in cobra venom factor-treated rats which had selectively impaired phagocytic functions. In these animals the effect of penicillin therapy was improved by increasing the daily dose and the frequency of injections and by earlier initiation of the therapy. The efficacy of penicillin in the cobra venom factor-treated rats was restored by markedly increasing the daily dose of penicillin or by increasing the daily dose in combination with a reduced interval of the penicillin injections.

引用

页码：376 / 387

页数：12

共 13 条

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