PSORIASIS RELATED TO ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS

被引:56
作者
WOLF, R [1 ]
TAMIR, A [1 ]
BRENNER, S [1 ]
机构
[1] TEL AVIV UNIV,SACKLER SCH MED,TEL AVIV,ISRAEL
来源
DERMATOLOGICA | 1990年 / 181卷 / 01期
关键词
captopril; Enalapril; immune response; pharmacologic response; psoriasis;
D O I
10.1159/000247861
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Two mechanisms have been proposed for the pathogenesis of eruptions induced by angiotensin-converting enzyme (ACE) inhibitors: (1) an allergic, immune-mediated reaction and (2) a pharmacologic, dose-dependent response. Two cases of palmoplantar psoriasis are presented, which can be attributed to the induction (case 1) and exacerbation (case 2) of ACE inhibitors. The first patient developed his eruption 2 months after he had received captopril, probably as a result of an allergic immunologic mechanism. This has been based mainly on circumstantial evidence and is further strengthened by the positive result of the mast cell degranulation test. The second patient developed an atenolol-induced, mild plantar psoriasis. She experienced a dramatic flare-up of her psoriatic lesions shortly after she had received an ACE inhibitor. It is suggested that her reaction occurred as a result of the enalapril-induced augmentation of kinin levels in the skin. These 2 patients represent deductive and unusual examples of the two different mechanisms that are responsible for the cutaneous complications of ACE inhibitors.
引用
收藏
页码:51 / 53
页数:3
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