THE HOX COMPLEX NEIGHBORED BY THE EVX GENE, AS WELL AS 2 OTHER HOMEOBOX-CONTAINING GENES, THE GBX-CLASS AND THE EN-CLASS, ARE LOCATED ON THE SAME CHROMOSOME-2 AND CHROMOSOME-7 IN HUMANS

被引：28

作者：

MATSUI, T

HIRAI, M

HIRANO, M

KUROSAWA, Y

机构：

[1] FUJITA HLTH UNIV,INST COMPREHENS MED SCI,TOYOAKE,AICHI 47011,JAPAN

[2] FUJITA HLTH UNIV,DEPT INTERNAL MED,TOYOAKE,AICHI 47011,JAPAN

[3] UNIV TOKYO,GRAD SCH SCI,DEPT ANTHROPOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

FEBS LETTERS | 1993年 / 336卷 / 01期

关键词：

HOMEOBOX GENE; LINKAGE GROUP; EVOLUTION;

D O I：

10.1016/0014-5793(93)81620-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two newly identified human homeobox-containing genes, GBX1 and GBX2, are closely related genes, as are members of the other homeobox genes, EN-1 and EN-2. GBX1 and EN-2 have been mapped to chromosome 7q36. The present study shows that GBX2 was mapped to chromosome 2q37. EN-1 was mapped to chromosome 2q14. Moreover, two HOX complexes neighbored by the EVX gene, HOXA and HOXD, are located at chromosome 7p15-p14 and 2q31-q37, respectively. Thus, it is possible that these homeobox genes were linked to each other on an ancestral genome and that the ancestral chromosome segment was duplicated during evolution.

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页码：107 / 110

页数：4

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