N-BROMOSUCCINIMIDE DIBROMODIMETHYLHYDANTOIN IN AQUEOUS BASE - A PRACTICAL METHOD FOR THE BROMINATION OF ACTIVATED BENZOIC-ACIDS

被引:93
作者
AUERBACH, J
WEISSMAN, SA
BLACKLOCK, TJ
ANGELES, MR
HOOGSTEEN, K
机构
[1] Merck Manufacturing Division Merck, Co., Inc., Rahway, NJ 07065
关键词
D O I
10.1016/S0040-4039(00)77457-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new bromination method employing NBS or dibromodimethylhydantoin in aqueous base is described for the synthesis of 3-bromo-2,6-dimethoxybenzoic acid (1) and other monobrominated alkoxybenzoic acids.
引用
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页码:931 / 934
页数:4
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