KINETICS OF SALICYLURIC ACID ELIMINATION IN MAN

被引：47

作者：

LEVY, G

AMSEL, LP

ELLIOTT, HC

机构：

[1] Department of Pharmaceutics School of Pharmacy, State University of New York, Buffalo, New York

[2] Departments of Chemistry and Medicine, University of Alabama, Birmingham, Alabama

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 07期

关键词：

Benzoic acid inhibition–salicyluric acid formation; Excretion rates–salicyluric acid; as test drug; as metabolite; Salicylate excretion–salicyluric acid formation rate effect; Salicyluric acid–elimination kinetics;

D O I：

10.1002/jps.2600580705

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The kinetics of salicyluric acid (SU) elimination were determined in healthy adult men from urinary excretion and (in one instance) plasma concentration data following intravenous injection of SU or oral administration of salicylate and subsequent blocking of further SU formation by benzoate. Similar results were obtained by the two methods. The elimination of SU is considerably more rapid than is suggested by urinary excretion data obtained after oral administration of SU in aqueous solution. The kinetics of SU formation from salicylate can be characterized adequately by considering the formation process as the rate‐limiting step in the excretion of SU after salicylate administration. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：827 / &

共 17 条

[1]

AMSEL LP, IN PRESS

[2] A KINETIC STUDY OF ELIMINATION OF SALICYLATE IN MAN [J].