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SELECTIVE EFFECT OF ACTINOMYCIN D ON FREE POLYRIBOSOMES OF MOUSE LIVER

被引：49
作者：
SARMA, DSR
REID, IM
SIDRANSKY, H
机构：
[1] Department of Pathology, University of Pittsburgh School of Medicine Pittsburgh
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 36卷 / 04期
关键词：
D O I：
10.1016/0006-291X(69)90344-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The administration of actinomycin D to fasted mice 12 hours before killing results in marked disaggregation of hepatic polyribosomes as determined by sucrose density gradients prepared from deoxycholate-treated postmitochondrial supernatants. This disaggregation of hepatic polyribosomes occurs in the free but not in the membrane-bound polyribosomes. Free, but not membrane-bound, polyribosomes of livers of actinomycin D-treated animals demonstrate decreased incorporation in vitro of 14C-leucine into proteins. © 1969.
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页码：582 / +
页数：1
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