MANUFACTURE AND PROPERTIES OF ERYTHROMYCIN BEADS CONTAINING NEUTRON-ACTIVATED ER-171

被引：14

作者：

PARR, AF ^{[1
]}

DIGENIS, GA ^{[1
]}

SANDEFER, EP ^{[1
]}

GHEBRESELLASSIE, I ^{[1
]}

IYER, U ^{[1
]}

NESBITT, RU ^{[1
]}

SCHEINTHAL, BM ^{[1
]}

机构：

[1] PARKE DAVIS & CO,DIV PHARMACEUT RES,MORRIS PLAINS,NJ 07950

来源：

PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 03期

关键词：

drug delivery system; erbium-171; erythromycin; erythromycin antimicrobial activity; erythromycin dissolution; gamma scintigraphy; neutron activation; radiolabeled dosage forms; scanning electron micrography;

D O I：

10.1023/A:1015826229323

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To evaluate the effects of a neutron activation radiolabeling technique on an enteric-coated multiparticulate formulation of erythromycin, test quantities were produced under industrial pilot scale conditions. The pellets contained the stable isotope erbium oxide (Er-170), which was later converted by neutron activation into the short-lived gamma ray-emitting radionuclide, erbium-171. In vitro studies indicated that the dissolution profile, acid resistance, and enteric-coated surface of the pellets were minimally affected by the irradiation procedure. Antimicrobial potency was also unaffected, as determined by microbiological assay. Neutron activation thus appears to simplify the radiolabeling of complex pharmaceutical dosage forms for in vivo study by external gamma scintigraphy. © 1990, Plenum Publishing Corporation. All rights reserved.

引用

页码：264 / 269

页数：6

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