DEPRESSION OF ALVEOLAR MACROPHAGE HYDROGEN-PEROXIDE AND SUPEROXIDE ANION RELEASE BY MINERAL DUSTS - CORRELATION WITH ANTIMONY, LEAD, AND ARSENIC CONTENTS

被引：15

作者：

GULYAS, H ^{[1
]}

LABEDZKA, M ^{[1
]}

GERCKEN, G ^{[1
]}

机构：

[1] UNIV HAMBURG,DEPT BIOCHEM,INST BIOCHEM & FOOD CHEM,W-2000 HAMBURG 13,GERMANY

来源：

ENVIRONMENTAL RESEARCH | 1990年 / 51卷 / 02期

关键词：

D O I：

10.1016/S0013-9351(05)80091-X

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Activated rabbit alveolar macrophages were incubated with airborne dusts from four West German sites (1 to 200 μg/106 cells) and waste incinerator fly ash fractions (50 to 500 μg/106 cells). Quartz dust DQ 12 (5 to 200 μg/106 cells) and Fe2O3 (0.05 to 50 μg/106 cells) were used as control dusts. The zymosan-stimulated hydrogen peroxide and superoxide anion release of the macrophages were not affected significantly by Fe2O3. All other investigated dusts decreased the two cell functions which were correlated negatively with surfaces, particle numbers, and antimony, lead, and arsenic contents of the dusts. The influence of heavy metal antagonisms and dust surfaces on dust toxicity against alveolar macrophages is discussed. © 1990 Academic Press, Inc.

引用

页码：218 / 229

页数：12

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