DETERMINATION OF THE MECHANISM OF DEMETHYLENATION OF (METHYLENEDIOXY)PHENYL COMPOUNDS BY CYTOCHROME-P450 USING DEUTERIUM-ISOTOPE EFFECTS

被引：24

作者：

FUKUTO, JM ^{[1
]}

KUMAGAI, Y ^{[1
]}

CHO, AK ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT PHARMACOL,LOS ANGELES,CA 90024

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 09期

关键词：

D O I：

10.1021/jm00113a028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The mechanism of demethylenation of (methylenedioxy)benzene (MDB), (methylenedioxy)amphetamine (MDA), and (methylenedioxy)methamphetamine (MDMA) by purified rabbit liver cytochrome P450IIB4 has been investigated by using deuterium isotope effects. A comparison of the magnitude and direction of the observed kinetic isotope effects indicates that the three compounds are demethylenated by different mechanisms. The different mechanisms of demethylenation have been proposed on the basis of comparisons o the observed biochemical isotope effects with the isotope effects from purely chemical systems.

引用

页码：2871 / 2876

页数：6

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