PATHOGENESIS OF CHRONIC BACTERIAL PROSTATITIS IN AN ANIMAL-MODEL

被引：55

作者：

NICKEL, JC

OLSON, ME

BARABAS, A

BENEDIKTSSON, H

DASGUPTA, MK

COSTERTON, JW

机构：

[1] UNIV CALGARY,DEPT BIOL SCI,CALGARY T2N 1N4,ALBERTA,CANADA

[2] UNIV CALGARY,FAC MORPHOL,CALGARY T2N 1N4,ALBERTA,CANADA

来源：

BRITISH JOURNAL OF UROLOGY | 1990年 / 66卷 / 01期

关键词：

D O I：

10.1111/j.1464-410X.1990.tb14864.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Summary— A reproducible rat model of chronic bacterial prostatitis was developed using a defined bacterial pathogen Escherichia coli to study the pathogenesis and persistence of chronic bacterial prostatitis. The progression of inflammation and its consequences from acute to chronic prostatitis were documented with microbiological, histological, ultrastructural and immunological data. Chronic bacterial prostatitis in this model was associated with sparse glycocalix‐enclosed protected bacterial microcolonies within the prostatic acini and ducts which appeared to stimulate a persistent local and systemic immunological reaction resulting in chronic inflammation of the gland. This model has many striking similarities to the natural history of human chronic bacterial prostatitis. © 1990 British Journal of Urology

引用

页码：47 / 54

页数：8

共 30 条

[1]

ABLIN RJ, 1971, J IMMUNOL, V107, P603

[2] GAMMA-GLOBULINS - QUANTITATIVE RELATIONSHIPS IN HUMAN SERUM AND NONVASCULAR FLUIDS [J].