DIRECT CHIRAL LIQUID-CHROMATOGRAPHIC SEPARATION OF TOCAINIDE ENANTIOMERS ON A CROWNPAK (CR) COLUMN AND ITS APPLICATION TO PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL-FLUIDS

被引：14

作者：

ABOULENEIN, HY ^{[1
]}

BAKR, SA ^{[1
]}

ISLAM, MR ^{[1
]}

ROTHCHILD, R ^{[1
]}

机构：

[1] CUNY JOHN JAY COLL CRIMINAL JUSTICE,DEPT SCI,NEW YORK,NY 10019

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1991年 / 14卷 / 19期

关键词：

D O I：

10.1080/01483919108049404

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Direct chiral liquid chromatographic resolution of racemic tocainide was accomplished without any derivatization using a crownpak CR(+) column as a chiral stationary phase. The stereochemical resolution (R) with symmetrical peaks was 0.97 and a separation factor (alpha) of 1.44 were obtained. Optimization of separation was achieved using different concentrations of perchloric acid.

引用

页码：3475 / 3481

页数：7

共 10 条

[1] MONITORING OF S-TOCAINIDE AND R-TOCAINIDE IN HUMAN-PLASMA AFTER HEPTAFLUOROBUTYRYLATION, SEPARATION ON CHIRASIL-VAL AND ELECTRON-CAPTURE DETECTION [J].

ANTONSSON, AM ;

GYLLENHAAL, O ;

KYLBERGHANSSEN, K ;

JOHANSSON, L ;

VESSMAN, J .

JOURNAL OF CHROMATOGRAPHY, 1984, 308 (JUN) :181-187

[2]

BLOCK AJ, 1988, J CARDIOVASC PHARM, V11, P216

[3] REVERSED-PHASE LC RESOLUTIONS OF CHIRAL ANTIARRHYTHMIC AGENTS VIA DERIVATIZATION WITH HOMOCHIRAL ISOTHIOCYANATES [J].

GAL, J ;

DESAI, DM ;

MEYERLEHNERT, S .

CHIRALITY, 1990, 2 (01) :43-51

[4] CURRENT CLASSIFICATION OF ANTIARRHYTHMIC DRUGS AS A GUIDE TO THEIR RATIONAL CLINICAL USE [J].

HARRISON, DC .

DRUGS, 1986, 31 (02) :93-95

[5] ANALYSIS AND STEREOSELECTIVE METABOLISM AFTER SEPARATE ORAL DOSES OF TOCAINIDE ENANTIOMERS TO HEALTHY-VOLUNTEERS [J].

HOFFMANN, KJ ;

RENBERG, L ;

GYLLENHAAL, O .

BIOPHARMACEUTICS & DRUG DISPOSITION, 1990, 11 (04) :351-363

[6] GAS-LIQUID-CHROMATOGRAPHIC RESOLUTION AND ASSAY OF TOCAINIDE ENANTIOMERS USING A CHIRAL CAPILLARY COLUMN AND STUDY OF THEIR SELECTIVE DISPOSITION IN MAN [J].

MCERLANE, KM ;

PILLAI, GK .

JOURNAL OF CHROMATOGRAPHY, 1983, 274 (MAY) :129-138

[7] DRUG-THERAPY - TOCAINIDE [J].

RODEN, DM ;

WOOSLEY, RL .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (01) :41-45

[8] CHIRAL SEPARATIONS OF CATIONIC AND ANIONIC DRUGS ON AN ALPHA-1-ACID GLYCOPROTEIN-BONDED STATIONARY PHASE (ENANTIOPAC) .2. INFLUENCE OF MOBILE PHASE ADDITIVES AND PH ON CHIRAL RESOLUTION AND RETENTION [J].

SCHILL, G ;

WAINER, IW ;

BARKAN, SA .

JOURNAL OF CHROMATOGRAPHY, 1986, 365 :73-88

[9] SIMULTANEOUS DETERMINATION OF THE ENANTIOMERS OF TOCAINIDE IN BLOOD-PLASMA USING GAS-LIQUID-CHROMATOGRAPHY WITH ELECTRON-CAPTURE DETECTION [J].

SEDMAN, AJ ;

GAL, J .

JOURNAL OF CHROMATOGRAPHY, 1984, 306 (MAR) :155-164

[10]

WIREBAUGH SR, 1990, 14TH INT S LIQ CHROM, P91

← 1 →