SYNTHESIS OF 2-CARBAMOYLMETHYL-6-BETA-D-RIBOFURANOSYLPYRIDINE WITH THE AID OF A PD(0)-CATALYZED REACTION

被引：12

作者：

DEVOS, E ^{[1
]}

ESMANS, EL ^{[1
]}

ALDERWEIRELDT, FC ^{[1
]}

BALZARINI, J ^{[1
]}

DECLERCQ, E ^{[1
]}

机构：

[1] KATHOLIEKE UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1993年 / 30卷 / 05期

关键词：

D O I：

10.1002/jhet.5570300513

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

D-Allo/D-altro-2-(2,4:3,5-di-O-benzylidenepentitol-1-yl)-6-ethoxycarbonylmethylpyridine was synthesized from 2-bromo-6-(2,4:3,5-di-O-benzylidenepentitol-1-yl)pyridine or 2-(2,4:3,5-di-O-benzylidenepentitol-1-yl)-6-iodopyridine by means of a tetrakis(triphenylphosphine)palladium(0)-catalyzed reaction with Reformatsky's reagent. Subsequent ammonolysis and mesylation of the D-altro-ethoxycarbonylmethyl compound gave D-altro-2-carbamoylmethyl-6-(1-O-mesyl-2,4:3,5-di-O-benzylidenepentitol-1-yl)pyridine which was cyclized to 2-carbamoylmethyl-6-beta-D-ribofuranoslpyridine.

引用

页码：1245 / 1252

页数：8

共 17 条

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