CLINICAL AND LABORATORY OBSERVATIONS - IMMUNOGENICITY AND SAFETY OF HAEMOPHILUS-INFLUENZAE TYPE-B TETANUS PROTEIN CONJUGATE VACCINE ALONE OR MIXED WITH DIPHTHERIA-TETANUSPERTUSSIS VACCINE IN INFANTS

被引：32

作者：

KAPLAN, SL

LAUER, BA

WARD, MA

WIEDERMANN, BL

BOYER, KM

DUKES, CM

SCHAFFER, DM

PAISLEY, J

MENDELSON, R

PEDREIRA, F

FRITZELL, B

机构：

[1] BAYLOR COLL MED, DEPT PEDIAT, HOUSTON, TX 77030 USA

[2] EMANUEL HOSP & HLTH CTR, DEPT PEDIAT, PORTLAND, OR USA

[3] RUSH MED COLL, DEPT PEDIAT, CHICAGO, IL USA

[4] GEORGE WASHINGTON UNIV, MED CTR, DEPT PEDIAT, WASHINGTON, DC 20037 USA

[5] CONNAUGHT LABS INC, SWIFTWATER, PA USA

来源：

JOURNAL OF PEDIATRICS | 1994年 / 124卷 / 02期

关键词：

D O I：

10.1016/S0022-3476(94)70328-0

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Haemophilus capsular polysaccharide-tetanus toroid conjugate (PRP-T) and diphtheria-tetanus-pertussis (DTP) vaccines were administered in a single syringe (group 1) or separate syringes (group 2) to 284 infants at 2, 4, and 6 months of age. Group 1 infants had a slightly greater incidence of local reactions. Systemic reactions were similar. The geometric mean titers of polyribosylribitol phosphate (PRP) serum antibody concentrations after the third dose of PRP-T vaccine were 4.8 and 4.3 mu g/ml for groups 1 and 2, respectively. Antibody responses to DTP antigens were also similar, The immunogenicity and safety of the PRP-T and DTP vaccines are equivalent when the vaccines are administered in separate syringes or the same syringe to infants.

引用

页码：323 / 327

页数：5

共 14 条

[1] [Anonymous], 1988, LANCET, Vi, P955
[2] HAEMOPHILUS-INFLUENZAE TYPE-B POLYSACCHARIDE-TETANUS PROTEIN CONJUGATE VACCINE DOES NOT DEPRESS SEROLOGIC RESPONSES TO DIPHTHERIA, TETANUS OR PERTUSSIS ANTIGENS WHEN COADMINISTERED IN THE SAME SYRINGE WITH DIPHTHERIA-TETANUS-PERTUSSIS VACCINE AT 2, 4 AND 6 MONTHS OF AGE
AVENDANO, A
FERRECCIO, C
LAGOS, R
HORWITZ, I
CAYAZZO, M
FRITZELL, B
MESCHIEVITZ, C
LEVINE, M
[J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1993, 12 (08) : 638 - 643
[3] IMPACT OF HAEMOPHILUS-INFLUENZAE TYPE-B POLYSACCHARIDE-TETANUS PROTEIN CONJUGATE VACCINE ON RESPONSES TO CONCURRENTLY ADMINISTERED DIPHTHERIA-TETANUS-PERTUSSIS VACCINE
CLEMENS, JD
FERRECCIO, C
LEVINE, MM
HORWITZ, I
RAO, MR
EDWARDS, KM
FRITZELL, B
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 267 (05): : 673 - 678
[4] CRAIG JP, 1992, MANUAL LAB IMMUNOLOG, P435
[5] EDWARDS KM, 1991, PEDIATRICS, V88, P1019
[6] SIMULTANEOUS ADMINISTRATION OF HEMOPHILUS-INFLUENZAE TYPE-B CAPSULAR POLYSACCHARIDE-DIPHTHERIA TOXOID CONJUGATE VACCINE WITH ROUTINE DIPHTHERIA-TETANUS-PERTUSSIS AND INACTIVATED POLIOVIRUS VACCINATIONS OF CHILDHOOD
ESKOLA, J
KAYHTY, H
GORDON, LK
HOVI, T
STENVIK, M
RONNBERG, PR
KELA, E
PELTOLA, H
[J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1988, 7 (07) : 480 - 484
[7] THE CLINICAL AND IMMUNOLOGICAL RESPONSE OF CHILEAN INFANTS TO HAEMOPHILUS-INFLUENZAE TYPE B-POLYSACCHARIDE-TETANUS PROTEIN CONJUGATE VACCINE COADMINISTERED IN THE SAME SYRINGE WITH DIPHTHERIA-TETANUS TOXOIDS-PERTUSSIS VACCINE AT 2, 4 AND 6 MONTHS OF AGE
FERRECCIO, C
CLEMENS, J
AVENDANO, A
HORWITZ, I
FLORES, C
AVILA, L
CAYAZZO, M
FRITZELL, B
CADOZ, M
LEVINE, M
[J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1991, 10 (10) : 764 - 771
[8] SAFETY AND IMMUNOGENICITY OF ACELLULAR DIPHTHERIA-TETANUS-PERTUSSIS AND HAEMOPHILUS CONJUGATE VACCINES GIVEN IN COMBINATION OR AT SEPARATE INJECTION SITES
KOVEL, A
WALD, ER
GUERRA, N
SERDY, C
MESCHIEVITZ, CK
[J]. JOURNAL OF PEDIATRICS, 1992, 120 (01) : 84 - 87
[9] SAFETY AND IMMUNOGENICITY OF HAEMOPHILUS-INFLUENZAE TYPE-B-NEISSERIA-MENINGITIDIS GROUP-B OUTER-MEMBRANE PROTEIN COMPLEX CONJUGATE VACCINE MIXED IN THE SYRINGE WITH DIPHTHERIA-TETANUS-PERTUSSIS VACCINE IN YOUNG GAMBIAN INFANTS
MULHOLLAND, EK
AHONKHAI, VI
GREENWOOD, AM
JONAS, LC
LUKACS, LJ
MINK, CM
STAUB, JM
TODD, J
VELLA, PP
GREENWOOD, BM
[J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1993, 12 (08) : 632 - 637
[10] PARADISO P, 1992, Pediatric Research, V31, p174A

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