Role of Dopamine D-1 and D-2 Receptors in Novelty-Maintained Place Preference

被引：55

作者：

Bardo, M. T. ^{[1
]}

Bowling, S. L. ^{[1
]}

Robinet, P. M. ^{[1
]}

Rowlett, J. K. ^{[1
]}

Lacy, M. ^{[1
]}

Mattingly, B. A. ^{[2
]}

机构：

[1] Univ Kentucky, Dept Psychol, 115 Kastle Hall, Lexington, KY 40506 USA

[2] Morehead State Univ, Dept Psychol, Morehead, KY 40351 USA

来源：

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY | 1993年 / 1卷 / 1-4期

关键词：

D O I：

10.1037/1064-1297.1.1-4.101

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Rats exposed to 1 of 2 different stimulus compartments showed a preference for the novel compartment. The novelty-maintained place preference was eliminated by the D-1 agonist SKF 38393 and the D-2 agonist quinpirole, but only at doses that also produced an impairment in locomotor activity. The novelty-maintained place preference was also eliminated by the D-1 antagonist SCH 23390, but not by the D-2 antagonist eticlopride. Both of the antagonist drugs tested produced a dose-dependent depression in locomotor activity. However, SCH 23390 was shown to block novelty-maintained place preference at a dose that had no significant effect on locomotor activity. These results indicate that D-1 receptors may play a role in the incentive value of novel stimuli.

引用

页码：101 / 109

页数：9

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