EFFECTS OF SUBLINGUALLY GIVEN NALOXONE IN OPIOID-DEPENDENT HUMAN VOLUNTEERS

被引：53

作者：

PRESTON, KL ^{[1
]}

BIGELOW, GE ^{[1
]}

LIEBSON, IA ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21224

来源：

DRUG AND ALCOHOL DEPENDENCE | 1990年 / 25卷 / 01期

关键词：

human subjects; methadone; naloxone; opioid antagonist; opioid withdrawal/physical dependence; sublingual administration;

D O I：

10.1016/0376-8716(90)90136-3

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

To determine whether sublingual naloxone could precipitate withdrawal in opioid-dependent subjects, naloxone was administered in increasing doses (0-8 mg in four or six sessions conducted over 2 days) to six heroin abusers and three methadone (30 mg/day, p.o.) maintenance patients. Two or three sessions were conducted per day with 2- to 2.5-h intervals between sameday sessions. Naloxone precipitated withdrawal in two of six heroin abusers and in all three methadone subjects. Naloxone is sufficiently absorbed sublingually to precipitate abstinence in dependent subjects, but naloxone doses up to 1-2 mg can be administered sublingually to opioid abusers/addicts without precipitating withdrawal. © 1990.

引用

页码：27 / 34

页数：8

共 17 条

[1] A CLINICAL-TRIAL OF BUPRENORPHINE - COMPARISON WITH METHADONE IN THE DETOXIFICATION OF HEROIN-ADDICTS [J].

BICKEL, WK ;

STITZER, ML ;

BIGELOW, GE ;

LIEBSON, IA ;

JASINSKI, DR ;

JOHNSON, RE .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1988, 43 (01) :72-78

[2]

BICKEL WK, 1988, J PHARMACOL EXP THER, V247, P47

[3]

DAYTON H B, 1970, Federation Proceedings, V29, P686

[4]

Fink M, 1970, Curr Psychiatr Ther, V10, P161

[5]

GRIFFITHS RR, 1980, J PHARMACOL EXP THER, V215, P649

[6] MORPHINE COMBINED WITH DOXAPRAM OR NALOXONE - STUDY OF POSTOPERATIVE PAIN RELIEF [J].

GUPTA, PK ;

DUNDEE, JW .

ANAESTHESIA, 1974, 29 (01) :33-39

[7]

HOFFMEISTER F, 1986, PSYCHOPHARMACOLOGY, V90, P441

[8]

JASINSKI DR, 1967, J PHARMACOL EXP THER, V157, P420

[9] NALOXONE AND NARCOTIC ABUSER - LOW-DOSE MAINTENANCE PROGRAM [J].

KURLAND, AA ;

HENDERSON, JM ;

KRANTZ, JC ;

KERMAN, F .

INTERNATIONAL JOURNAL OF THE ADDICTIONS, 1973, 8 (01) :127-141

[10]

LEGROS J, 1984, ARCH INT PHARMACOD T, V271, P11

← 1 2 →