CONDUCTION IN THE GIANT NERVE-FIBER PATHWAY IN TEMPERATURE-SENSITIVE PARALYTIC MUTANTS OF DROSOPHILA

被引:34
作者
ELKINS, T [1 ]
GANETZKY, B [1 ]
机构
[1] UNIV WISCONSIN, GENET LAB, MADISON, WI 53706 USA
关键词
Action potentials; Cervical giant fiber pathway; Membrane excitability; Sodium channels;
D O I
10.3109/01677069009107111
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
To study electrogenic conduction in neurons of the cervical giant nerve fiber (CGF) pathway in Drosophiia adults carrying temperature -sensitive paralytic mutations that affect sodium channels, we recorded dorsal longitudinal muscle (DLM) responses evoked by electrical stimulation of the brain. In the mutants tipE, napts and parats, conduction in certain neurons presynaptic to the CGF failed at about the same temperature at which paralysis occurred in each mutant. Conduction in the CGF and neurons postsynaptic to it remained active in all mutants even at very elevated temperatures. In contrast, analysis of sei mutants showed enhanced spontaneous activity at elevated temperatures in at least some neurons of the CGF pathway. The implications of these results with respect to the normal in vivo functions of these genes in neuronal signalling are considered. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码:207 / 219
页数:13
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