ANTITUMOR PRINCIPLES FROM IXORA-JAVA']JAVANICA

被引:24
作者
NAIR, SC
PANIKKAR, KR
机构
[1] Amala Cancer Research Centre, Trichur, 680 553 Kerala, Amala Nagar
关键词
antitumor; Dalton's lymphoma; Ehrlisch carcinoma; Ixora [!text type='java']java[!/text]nica;
D O I
10.1016/0304-3835(90)90147-P
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The antitumour agent from Ixora javanica flowers shows broad activity against transplantable solid tumours (DLA) in mice by inhibiting the growth of tumour and arresting the growth of already formed tumours; with lesser activity against Ascites tumours. In vitro cytotoxic studies showed 50% cytotoxicity to Dalton's lymphoma (DLA) and Ehrlich Ascites tumour cells at a concentration of 12 μg and 65 μg, respectively, with no activity against normal lymphocytes but preferential activity for lymphocytes derived from leukemia patients (ALL) (CML), and K 562 suspension cell culture. Tritiated thymidine incorporation studies indicated the mechanism of action of the agent at the site of DNA synthesis. The purified fractions contained Ferulic acid, Pyrocatacheuic acid and caffeic acid. © 1990.
引用
收藏
页码:121 / 126
页数:6
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