ENHANCING PENICILLIN FERMENTATIONS BY INCREASED OXYGEN SOLUBILITY THROUGH THE ADDITION OF NORMAL-HEXADECANE

被引：61

作者：

HO, CS

JU, LK

BADDOUR, RF

机构：

[1] UNIV AKRON, DEPT CHEM ENGN, AKRON, OH 44325 USA

[2] CHARLES RIVER LABS INC, WILMINGTON, MA 01887 USA

[3] MIT, DEPT CHEM ENGN, CAMBRIDGE, MA 02139 USA

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 1990年 / 36卷 / 11期

关键词：

Mold Spore Cell Cultures - Oxygen Transfer Enhancers - Penicillin Fermentation Media - Penicillin Production - Submerged Aerobic Fermentation;

D O I：

10.1002/bit.260361106

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

n‐Hexadecane was added to fermentation media to increase the medium oxygen solubilities, thus enhancing oxygen transfer rates in penicillin fermentations. For shake flask fermentations, cells were found to grow faster in the flasks with n‐hexadecane than those without. The addition of n‐hexadecane to penicillin fermentations was shown to significantly increase cell growth and penicillin production and reduce formation of mycelial pellets. The result was attributed to the enhancement of oxygen transfer in mycelial fermentations due to the higher oxygen solubilities of fermentation media achieved by adding n‐hexadecane. Copyright © 1990 John Wiley & Sons, Inc.

引用

页码：1110 / 1118

页数：9

共 19 条

[1] THE SOLUBILITY OF OXYGEN AND OZONE IN LIQUIDS [J].