GERM-CELL DEFICIENT (GCD), AN INSERTIONAL MUTATION MANIFESTED AS INFERTILITY IN TRANSGENIC MICE

被引：83

作者：

PELLAS, TC ^{[1
]}

RAMACHANDRAN, B ^{[1
]}

DUNCAN, M ^{[1
]}

PAN, SS ^{[1
]}

MARONE, M ^{[1
]}

CHADA, K ^{[1
]}

机构：

[1] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT BIOCHEM,675 HOES LANE,PISCATAWAY,NJ 08854

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 19期

关键词：

PRIMORDIAL GERM CELLS; GENETICS; PREMATURE OVARIAN FAILURE;

D O I：

10.1073/pnas.88.19.8787

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A genetic analysis is necessary to gain a greater understanding of the complex developmental processes in mammals. Toward this end, an insertional transgenic mouse mutant has been isolated that results in abnormal germ-cell development. This recessive mutation manifests as infertility in both males and females and is specific for the reproductive organs, since all other tissues examined were histologically normal. A developmental analysis of the gonadal tissues demonstrated that the germ cells were specifically depleted as early as day 11.5 of embryonic development, while the various somatic cells were apparently unaffected. Therefore, the mutated locus must play a critical role in the migration/proliferation of primordial germ cells to the genital ridges of developing embryos. In addition, females homozygous for the mutation could potentially be a valuable animal model of a human syndrome, premature ovarian failure. This mutation has been named germ-cell deficient, gcd.

引用

页码：8787 / 8791

页数：5

共 27 条

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