PROSTACYCLIN (PGI2) AND THE EFFECT OF PHOSPHODIESTERASE INHIBITORS ON PLATELET-AGGREGATION

被引：32

作者：

JORGENSEN, KA

DYERBERG, J

STOFFERSEN, E

机构：

[1] Coagulation Laboratory, Aalborg Hospital

来源：

PHARMACOLOGICAL RESEARCH COMMUNICATIONS | 1979年 / 11卷 / 07期

关键词：

D O I：

10.1016/S0031-6989(79)80032-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It can be expected, that phosphodiesterase inhibitors potentiat and prolong the effect of prostacyclin (PGI2) on platelet aggregation, since PGI2 is believed to be a stimulator of adenylcyclase. The effect of PGI2 on thrombin induced aggregation of washed, acetylated platelets was greatly prolonged by the phosphodiesterase inhibitors theophylline and dipyridamole. A potentiating effect was also demonstrated. © 1979 The Italian Pharmacological Society.

引用

页码：605 / 615

页数：11

共 18 条

[1] CHEMICAL STABILITY OF PROSTACYCLIN (PGI2) IN AQUEOUS-SOLUTIONS [J].