PASTEURELLA-HAEMOLYTICA LEUKOTOXIN ENHANCES PRODUCTION OF LEUKOTRIENE-B4 AND 5-HYDROXYEICOSATETRAENOIC ACID BY BOVINE POLYMORPHONUCLEAR LEUKOCYTES

被引：41

作者：

HENRICKS, PAJ ^{[1
]}

BINKHORST, GJ ^{[1
]}

DRIJVER, AA ^{[1
]}

NIJKAMP, FP ^{[1
]}

机构：

[1] UNIV UTRECHT,FAC VET MED,DEPT LARGE ANIM SCI,3508 TD UTRECHT,NETHERLANDS

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 08期

关键词：

D O I：

10.1128/IAI.60.8.3238-3243.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The influence of the leukotoxin of Pasteurella haemolytica on the generation of arachidonic acid metabolites by bovine polymorphonuclear leukocytes (PMNs) was investigated. PMNs released 5-, 12-, and 15-hydroxyeicosatetraenoic acids (5-, 12-, and 15-HETE) and leukotriene B4 (LTB4) upon stimulation with arachidonic acid. The leukotoxin preparations dose dependently enhanced the release of the 5-lipoxygenase products 5-HETE and LTB4 in arachidonic acid-stimulated PMNs, whereas the release of 12- and 15-HETE was not affected. The enhanced release of LTB4 and 5-HETE was not due to a decreased cellular retention of the 5-lipoxygenase products. In addition, leukotoxin preparations by themselves were also able to induce LTB4 and 5-HETE production in the absence of exogenous arachidonic acid. Generation of 5-lipoxygenase products by PMNs stimulated by leukotoxin may represent an important cellular event that occurs during infections with P. haemolytica.

引用

页码：3238 / 3243

页数：6

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