RETENTION MECHANISM OF ENANTIOMERIC SEPARATION BY LIQUID-CHROMATOGRAPHY WITH MICELLAR BILE-SALT MOBILE PHASES

被引：18

作者：

HU, W

TAKEUCHI, T

HARAGUCHI, H

机构：

[1] NAGOYA UNIV,SCH ENGN,DEPT APPL CHEM,CHIKUSA KU,NAGOYA 46401,JAPAN

[2] NAGOYA UNIV,RESOURCE & ENERGY CONSERVAT RES CTR,CHIKUSA KU,NAGOYA 46401,JAPAN

来源：

CHROMATOGRAPHIA | 1992年 / 33卷 / 1-2期

关键词：

COLUMN LIQUID CHROMATOGRAPHY; MICELLAR BILE-SALT MOBILE PHASE; ENANTIOMERIC RESOLUTION; RETENTION MODEL;

D O I：

10.1007/BF02276854

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The retention mechanism involved in enantiomeric separation of binaphthyl compounds by HPLC with micellar bile-salt mobile phases is discussed. A new model for the equilibrium is proposed, in which a heterogeneous stationary phase comprising solvated and micelle-adsorbed portions is considered. The experimental data supported the adsorption of the bile salt micelles on the octadecylsilica stationary phase which could recognize the chirality of binaphthyl compounds.

引用

页码：63 / 66

页数：4

共 9 条

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