TREATMENT OF FOXGLOVE EXTRACT POISONING WITH DIGOXIN-SPECIFIC FAB FRAGMENTS

被引：25

作者：

RICH, SA

LIBERA, JM

LOCKE, RJ

机构：

[1] Pharmacy and Therapeutics Committee, FF Thompson Hospital, Canandaigua, NY

来源：

ANNALS OF EMERGENCY MEDICINE | 1993年 / 22卷 / 12期

关键词：

FAB FRAGMENTS; FOXGLOVE OVERDOSE;

D O I：

10.1016/S0196-0644(05)80420-2

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

A 22-year-old man presented to our emergency department after an intentional overdose of a homemade foxglove extract. Clinical symptoms with symptomatic bradyarrhythmia and ECG changes were consistent with cardiac glycoside poisoning. Treatment with digoxin-specific Fab fragments resulted in transient clinical and ECG improvement. Serum immunoassay demonstrated a digitoxin-like glycoside. The serum levels showed no evidence of altered elimination or distribution with Fab therapy despite temporary improvements in the clinical course. The use of Fab did not result in a shortened clinical course in this episode of foxglove poisoning, as one would expect in the setting of commercial glycoside product poisoning.

引用

页码：1904 / 1907

页数：4

共 10 条

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