INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE HIGHEST LEVELS IN THE DENDRITIC SPINES OF CEREBELLAR PURKINJE-CELLS AND HIPPOCAMPAL CA1 PYRAMIDAL CELLS - A PREEMBEDDING AND POSTEMBEDDING IMMUNOELECTRON MICROSCOPIC STUDY

被引：18

作者：

GO, M

UCHIDA, T

TAKAZAWA, K

ENDO, T

ERNEUX, C

MAILLEUX, P

ONAYA, T

机构：

[1] UNIV YAMANASHI, SCH MED,DEPT INTERNAL MED 3,1110 SIMOKATOU, 1110 SIMOKATOU,TAMAHO CHO, YAMANASHI 40938, JAPAN

[2] HIROSHIMA UNIV, SCH DENT, DEPT ORAL ANAT 2, HIROSHIMA 730, JAPAN

[3] UNIV LIBRE BRUXELLES, FAC MED, NEUROPHYSIOL & NEUROPEPTIDE RES LAB, B-1050 BRUSSELS, BELGIUM

来源：

NEUROSCIENCE LETTERS | 1993年 / 158卷 / 02期

关键词：

INSP3; 3-KINASE; INSP4; ULTRASTRUCTURE; DENDRITIC SPINE; PURKINJE CELL; PYRAMIDAL CELL; HIPPOCAMPAL CA1;

D O I：

10.1016/0304-3940(93)90247-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inositol 1,4,5-trisphosphate 3-kinase (InsP3 3-kinase) plays a crucial role in calcium homeostasis by regulating InsP3 levels. We have reported the highest concentrations of InsP3 3-kinase in the dendrites of cerebellar Purkinje cells and hippocampal pyramidal cells of the CAl sector of the Ammon's horn. We here investigate its subcellular localization by pre- and post-embedding immunoelectron microscopic study. In both populations of neurons, the major structure expressing a high level of InsP3 3-kinase is the dendritic spines.

引用

页码：135 / 138

页数：4

共 24 条

[1] INOSITOL TRISPHOSPHATE, A NOVEL 2ND MESSENGER IN CELLULAR SIGNAL TRANSDUCTION [J].