SELECTIVE DEPLETION OF V-BETA-BEARING T-CELLS IN PATIENTS WITH SEVERE INVASIVE GROUP-A STREPTOCOCCAL INFECTIONS AND STREPTOCOCCAL TOXIC SHOCK SYNDROME

被引:92
作者
WATANABEOHNISHI, R
LOW, DE
MCGEER, A
STEVENS, DL
SCHLIEVERT, PM
NEWTON, D
SCHWARTZ, B
KREISWIRTH, B
SCRIVER, S
GREEN, K
CANN, D
GOLD, W
DEMERS, B
SIMOR, A
LOVGREN, M
TALBOT, J
KOTB, M
机构
[1] UNIV TENNESSEE,VET ADM MED CTR,DEPT SURG,MEMPHIS,TN 38104
[2] UNIV TENNESSEE,DEPT MICROBIOL & IMMUNOL,MEMPHIS,TN
[3] VET ADM MED CTR,MEMPHIS,TN
[4] MT SINAI HOSP,DEPT MICROBIOL,TORONTO,ON,CANADA
[5] PRINCESS MARGARET HOSP,DEPT MICROBIOL,TORONTO,ON,CANADA
[6] VET ADM MED CTR,BOISE,ID
[7] UNIV MINNESOTA,MINNEAPOLIS,MN
[8] CTR DIS CONTROL & PREVENT,ATLANTA,GA
[9] TB CTR,PUBL HLTH RES INST,NEW YORK,NY
关键词
D O I
10.1093/infdis/171.1.74
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The V beta repertoire of T cells of patients with gram-positive group A streptococcal (GAS) and non-GAS infections was analyzed to seek evidence for the role of superantigens in streptococcal toxic shock syndrome. No evidence of VB overexpression but a consistent pattern of depletion of V beta 1, V beta 5.1 and V beta 12 was observed in patients with severe GAS infections, This pattern of V beta depletion was not observed in patients with nonsevere GAS infections or with severe non-GAS gram-positive infections. T cells from patients with severe GAS infections showed evidence of apoptosis; no apoptosis was found when there was no evidence of V beta depletion. There was no correlation with streptococcal M or T serotype or known spe genes. The depletion of specific V beta-hearing T cells in patients with severe GAS infections supports the role of a superantigen in these infections. The in vivo pattern of VP specificity implicates a novel superantigen(s) in this disease.
引用
收藏
页码:74 / 84
页数:11
相关论文
共 72 条
[1]  
ABE J, 1991, J IMMUNOL, V146, P3747
[2]   SELECTIVE EXPANSION OF T-CELLS EXPRESSING T-CELL RECEPTOR VARIABLE REGIONS V-BETA-2 AND V-BETA-8 IN KAWASAKI-DISEASE [J].
ABE, J ;
KOTZIN, BL ;
JUJO, K ;
MELISH, ME ;
GLODE, MP ;
KOHSAKA, T ;
LEUNG, DYM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (09) :4066-4070
[3]  
AYOUB EM, 1962, PEDIATRICS, V29, P527
[4]   TOXIC STREP SYNDROME - A MANIFESTATION OF GROUP-A STREPTOCOCCAL INFECTION [J].
BARTTER, T ;
DASCAL, A ;
CARROLL, K ;
CURLEY, FJ .
ARCHIVES OF INTERNAL MEDICINE, 1988, 148 (06) :1421-1424
[5]   ASSOCIATION OF EXOTOXIN-PRODUCING GROUP-A STREPTOCOCCI AND SEVERE DISEASE IN CHILDREN [J].
BELANI, K ;
SCHLIEVERT, PM ;
KAPLAN, EL ;
FERRIERI, P .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1991, 10 (05) :351-354
[6]   A ROLE FOR CLONAL INACTIVATION IN T-CELL TOLERANCE TO MLS-1A [J].
BLACKMAN, MA ;
BURGERT, HG ;
WOODLAND, DL ;
PALMER, E ;
KAPPLER, JW ;
MARRACK, P .
NATURE, 1990, 345 (6275) :540-542
[7]   STAPHYLOCOCCAL AND STREPTOCOCCAL PYROGENIC TOXINS INVOLVED IN TOXIC SHOCK SYNDROME AND RELATED ILLNESSES [J].
BOHACH, GA ;
FAST, DJ ;
NELSON, RD ;
SCHLIEVERT, PM .
CRITICAL REVIEWS IN MICROBIOLOGY, 1990, 17 (04) :251-272
[8]   SEVERE STREPTOCOCCAL AXILLARY LYMPHADENITIS [J].
BOYCE, JM .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (10) :655-658
[9]   SELECTIVE EXPANSION OF T-CELLS EXPRESSING V-BETA-2 IN TOXIC SHOCK SYNDROME [J].
CHOI, YW ;
LAFFERTY, JA ;
CLEMENTS, JR ;
TODD, JK ;
GELFAND, EW ;
KAPPLER, J ;
MARRACK, P ;
KOTZIN, BL .
JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (03) :981-984
[10]   INTERACTION OF STAPHYLOCOCCUS-AUREUS TOXIN SUPERANTIGENS WITH HUMAN T-CELLS [J].
CHOI, YW ;
KOTZIN, B ;
HERRON, L ;
CALLAHAN, J ;
MARRACK, P ;
KAPPLER, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :8941-8945