EFFECT OF [DL]-ALPHA-TOCOPHEROL ON FECL2-INDUCED LIPID-PEROXIDATION IN RAT AMYGDALA

被引：10

作者：

TRIGGS, WJ

WILLMORE, LJ

机构：

[1] UNIV FLORIDA,COLL MED,DEPT NEUROL,GAINESVILLE,FL

[2] UNIV TEXAS,SCH MED,DEPT NEUROL,HOUSTON,TX 77030

来源：

NEUROSCIENCE LETTERS | 1994年 / 180卷 / 01期

关键词：

LIPID PEROXIDATION; ALPHA-TOCOPHEROL; BRAIN INJURY; IRON; RAT;

D O I：

10.1016/0304-3940(94)90907-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Peroxidative injury of neural membrane lipids can be initiated by iron-containing blood products, chelated ferrous or ferric ions, and low valence iron in aqueous solution. Lipid peroxidation was measured following focal injection of 3 mu l of 100 mM FeCl2, into rat amygdala. Acute parenteral administration of [dl]-alpha-tocopherol as the alcohol limited the quantity of peroxidation products generated. These data suggest a potential role for alpha-tocopherol administration in limiting brain injury responses.

引用

页码：33 / 36

页数：4

共 36 条

[1]

Aisen P., 1977, CIBA F S, V51, P1

[2]

Anderson D.K., 1983, NEUROCHEM PATHOL, V1, P249

[3]

[Anonymous], 1979, STEREOTAXIC ATLAS RA

[4]

AUST SD, 1982, FREE RADICALS BIOL, P1