OG4C3 CIRCULATING ANTIGEN - A MARKER OF INFECTION AND ADULT WORM BURDEN IN WUCHERERIA-BANCROFTI FILARIASIS

被引：99

作者：

CHANTEAU, S ^{[1
]}

MOULIAPELAT, JP ^{[1
]}

GLAZIOU, P ^{[1
]}

NGUYEN, NL ^{[1
]}

LUQUIAUD, P ^{[1
]}

PLICHART, C ^{[1
]}

MARTIN, PMV ^{[1
]}

CARTEL, JL ^{[1
]}

机构：

[1] INST TERR RECH MED LOUIS MALARDE, PAPEETE, French Polynesi, FRANCE

来源：

JOURNAL OF INFECTIOUS DISEASES | 1994年 / 170卷 / 01期

关键词：

D O I：

10.1093/infdis/170.1.247

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Og4C3 circulating filarial antigen was detected in the sera of 94.5% (259/274) of microfilaremic patients, 32% (239/751) of persons with presumption of filariasis, and 23% (11/48) of chronic filariasis patients. The antigen level was correlated with the microfilariae (Mf) density and patient age (P < .01). It remained stable in patients treated with microfilaricidal drugs. Og4C3 antigen, undetectable in Mf culture media, was demonstrated to be a rare somatic Mf antigen. It appears to be an excreted or secreted antigen from adult filaria. It could be used as a marker of infection and an indicator of adult worm burden.

引用

页码：247 / 250

页数：4

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