MUTAGENIC PROPERTIES OF ETHYLIDENE GYROMITRIN AND ITS METABOLITES IN MICROSOMAL ACTIVATION TESTS AND IN HOST-MEDIATED ASSAY

被引：10

作者：

VONWRIGHT, A

NISKANEN, A

PYYSALO, H

机构：

[1] Technical Research Centre of Finland, Food Research Laboratory, SF-02150 Espoo 15

来源：

MUTATION RESEARCH | 1978年 / 54卷 / 02期

关键词：

D O I：

10.1016/0165-1161(78)90037-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ethylidene gyromitrin (acetaldehyde-N-methyl-N-formylhydrazone) is the main poisonous hydrazine derivative in the edible mushroom false morel (Gyromitra esculenta Pers. Fr.). The mutagenic properties of this compound, and of its metabolites N-methyl-N-formylhydrazine and N-methylhydrazine, were tested by microsomal activation and host-mediated asaay. Histidine auxotroph strains of Salmonella typhimurium were used as indicator organisms. Microsomal preparations had no detectable effect on the biological activity of the compounds tested, but the results of host-mediated assay experiments suggested that a bacteriocidic metabolite is formed from ethylidene gyromitrin. © 1978.

引用

页码：167 / 173

页数：7

共 15 条

[1] IMPROVED BACTERIAL TEST SYSTEM FOR DETECTION AND CLASSIFICATION OF MUTAGENS AND CARCINOGENS [J].