FUNCTIONALIZATION OF STEROID SIDE-CHAINS - CONVERSION OF CHOLESTEROL TO CHOL-5-ENE-3-BETA, 24-DIOL

被引：15

作者：

DENO, NC

MEYER, MD

机构：

[1] Department of Chemistry, The Pennsylvania State University, Pennsylvania 16802, University Park

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 19期

关键词：

D O I：

10.1021/jo01333a022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cholesterol has been converted to choI-5-ene-3/3, 24-diol in a 14% overall yield. The three-step process involves protection of the double bond of cholesterol as 6/3-acetamido-5a-cholestan-3/3-ol acetate (1), elimination of the three terminal carbons of the side chain by a novel oxidative cleavage with trifluoroperoxyacetic acid, and elimination of acetamide to restore the 5, 6 double bond. © 1979, American Chemical Society. All rights reserved.

引用

页码：3383 / 3385

页数：3

共 16 条

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