A VOLTAGE-DEPENDENT CHLORIDE CURRENT LINKED TO THE CELL-CYCLE IN ASCIDIAN EMBRYOS

被引：65

作者：

BLOCK, ML ^{[1
]}

MOODY, WJ ^{[1
]}

机构：

[1] UNIV WASHINGTON,DEPT ZOOL,SEATTLE,WA 98195

来源：

SCIENCE | 1990年 / 247卷 / 4946期

关键词：

D O I：

10.1126/science.2309122

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A voltage-dependent chloride current has been found in early ascidian embryos that is a minor conductance in the oocyte and in interphase blastomeres but that increases transiently in amplitude by more than tenfold during each cell division. Repeated cycles in the density of this chloride current could be recorded for up to 6 hours (four cycles) in cleavage-arrested embryos, whether they were activated by sperm or calcium ionophore. These data suggest that there is a direct link between the cell cycle clock and the properties of this channel, a link that results in pronounced cyclical changes in the electrical properties of early blastomeres.

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页码：1090 / 1092

页数：3

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