GENOTOXIC EFFECTS AND CHEMICAL-COMPOSITIONS OF 4 CREOSOTES

被引：44

作者：

NYLUND, L ^{[1
]}

HEIKKILA, P ^{[1
]}

HAMEILA, M ^{[1
]}

PYY, L ^{[1
]}

LINNAINMAA, K ^{[1
]}

SORSA, M ^{[1
]}

机构：

[1] OULU REG INST OCCUPAT HLTH,OULU,FINLAND

来源：

MUTATION RESEARCH | 1992年 / 265卷 / 02期

关键词：

COMPLEX MIXTURES; GENOTOXICITY; CHEMICAL COMPOSITION;

D O I：

10.1016/0027-5107(92)90051-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Four creosotes used in Finland for impregnating wood were tested in the Ames Salmonella test, the SCE test and the SOS chromotest. Compounds volatile at 37-degrees-C were assayed using the taped plate testing protocol. The creosotes were fractionated according to their natural boiling ranges and the fractions were tested in the Ames Salmonella assay. Chemical compositions of creosotes and fractions were determined by high resolution gas chromatography/mass spectrophotometry techniques and by reversed phase high performance liquid chromatography. Mutagenic activities were shown to reside in fractions having the highest boiling point ranges (> 290-degrees-C). The concentrations of mutagenic polycyclic aromatic hydrocarbons in creosotes and in some of their corresponding distillation fractions, when compared with mutagenic activities, indicated synergistic or antagonistic interactions.

引用

页码：223 / 236

页数：14

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