EFFECT OF EGF ON THE CORNEAL WOUND-HEALING OF ALLOXAN DIABETIC MICE

被引:17
作者
GONUL, B
KOZ, M
ERSOZ, G
KAPLAN, B
机构
[1] Department of Physiology, Faculty of Medicine, Gazi University, Besevler
关键词
CORNEAL WOUND HEALING; ALLOXAN DIABETES; EGF; MICE;
D O I
10.1016/0014-4835(92)90130-K
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
We identified the local treatment effect of epidermal growth factor on corneal wound healing of alloxan diabetic mice. The corneal wounds were induced by 0·5 m NaOH solution on the corneal surfaces of the diabetic and non-diabetic groups. The local epidermal growth factor solution (100 ng ml-1) was dropped in 5-μl aliquots into the eye twice a day. The corneal wounds were measured daily for 15 days and examined histologically at the end of 15th day of experimental period. The results indicated that topical epidermal growth factor treatment of diabetic and non-diabetic mice greatly improved the incidence of healing of wounded corneas. © 1992.
引用
收藏
页码:519 / 524
页数:6
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