UPTAKE AND RELEASE OF BETA-ALANINE IN CEREBELLAR GRANULE CELLS IN PRIMARY CULTURE - REGULATION OF RELEASE BY GLUTAMATERGIC AND GABAERGIC RECEPTORS

被引：17

作者：

SARANSAARI, P

OJA, SS

机构：

[1] Tampere Brain Research Center, Department of Biomedical Sciences, University of Tampere, SF-33101 Tampere

来源：

NEUROSCIENCE | 1993年 / 53卷 / 02期

关键词：

D O I：

10.1016/0306-4522(93)90211-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The uptake and release of beta-[H-3]alanine were studied in cultured glutamatergic cerebellar granule cells of the rat. The uptake of beta-alanine was saturable and sodium-dependent, comprising one high-affinity transport component. It was inhibited by hypotaurine, taurine, GABA and homotaurine but not by glycine or glutamate. The release was enhanced by homoexchange, veratridine and high K+ concentrations (50 mM). The K+-stimulated release was at least partially Ca2+-dependent. The release was shown to be subject to regulation by GABA(A) receptors and glutamate receptors of the kainate type. The results signify that beta-alanine may have a functional role in cerebellar granule cells.

引用

页码：475 / 481

页数：7

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