EFFECTS OF GOLD SODIUM THIOMALATE, CYCLOSPORINE-A, CYCLOPHOSPHAMIDE, AND PLACEBO ON COLLAGEN-INDUCED ARTHRITIS IN RATS

被引：12

作者：

CANNON, GW

MCCALL, S

COLE, BC

RADOV, LA

WARD, JR

GRIFFITHS, MM

机构：

[1] UNIV UTAH,SCH MED,DIV RHEUMATOL,SALT LAKE CITY,UT 84112

[2] UNIV UTAH,SCH MED,DEPT INTERNAL MED,SALT LAKE CITY,UT 84112

[3] FISON PHAMACEUT,ROCHESTER,NY

来源：

AGENTS AND ACTIONS | 1993年 / 38卷 / 3-4期

关键词：

D O I：

10.1007/BF01976216

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

The prophylactic and therapeutic effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis (CIA) were evaluated in DA rats. Prophylactic treatment with cyclosporin A and cyclophosphamide suppressed the arthritis incidence, clinical inflammation, destructive bone changes, and development of anti-collagen antibody in DA rats subsequently injected with porcine type-II collagen. Therapeutic treatment with cyclosporin A and cyclophosphamide had a definite suppression on established CIA when started 21 days after the initial collagen injection, but the suppression was less marked than that of prophylactic treatment. Gold had no impact on CIA in DA rats when administered either prophylactically or therapeutically.

引用

页码：240 / 246

页数：7

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