SYNTHESIS OF SOMATOSTATIN ANALOGS INCORPORATING NUCLEO AMINO-ACIDS

被引:10
作者
LEWIS, I
BRUNS, C
机构
[1] Sandoz Pharma Ltd.
关键词
D O I
10.1016/S0040-4020(01)90476-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Somatostatin analogues incorporating nucleo amino acids have been chemically synthesised by both solution phase coupling of protected fragments and solid phase methods. Methodology is presented enabling the preparation of these previously unknown reduced size somatostatin analogues. The observation of high biological activity with modified receptor binding affinities and levels of inhibition of growth hormone release from cultured pituitary cells is discussed.
引用
收藏
页码:7485 / 7494
页数:10
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