Air pollution involving nitrogen dioxide exposure and wheezing bronchitis in children

被引：123

作者：

Pershagen, G

Rylander, E

Norberg, S

Eriksson, M

Nordvall, SL

机构：

[1] KAROLINSKA HOSP,DEPT PEDIAT,S-10401 STOCKHOLM,SWEDEN

[2] ST GORANS UNIV HOSP,STOCKHOLM,SWEDEN

[3] KAROLINSKA HOSP,DEPT ENVIRONM HLTH & INFECT DIS CONTROL,S-10401 STOCKHOLM,SWEDEN

来源：

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | 1995年 / 24卷 / 06期

关键词：

air pollution; bronchitis; case-control; children; nitrogen dioxide; wheezing;

D O I：

10.1093/ije/24.6.1147

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background. A population-based case-control study was performed in Stockholm to assess the influence of air pollution on the occurrence of severe wheezing bronchitis in children. Methods. The study included 197 children aged 4 months to 4 years, who were hospitalized because of breathing difficulties with wheezing, and 350 population controls. Information on potential risk factors for childhood wheezing and a residential history was obtained at home interview with parents. Outdoor nitrogen dioxide (NO2) concentrations at home 2 addresses and day care centres from birth on were estimated from validated models, mainly using data on traffic intensity from municipal registers. Results. The risk of wheezing bronchitis was related to time-weighted mean outdoor NO2 exposure in girls (P = 0.02), but 2 not in boys. A gas stove in the home appeared to be a risk factor primarily for girls. All analyses controlled for parental asthma and maternal smoking, which were independent risk factors for wheezing bronchitis. Conclusions. The results suggest that exposure to combustion products containing NO2 may be of particular importance for the development of wheezing bronchitis in girls.

引用

页码：1147 / 1153

页数：7

共 43 条

[1]

(1987)

[2]

Samet J.M., Utell M.J., The risk of nitrogen dioxide: What have we learned from epidemiological and clinical studies?, Toxicol Ind Health, 6, pp. 247-262, (1990)

[3]

Skoner D., Caliguiri L., The wheezing infant, Pediatr Clin North Am, 35, (1988)

[4]

Palmieri J., Longobardi G., Napolitano G., Simonetto D.M.L., Parental smoking and asthma in childhood, Eur J Pediatr, 149, pp. 738-740, (1990)

[5]

Wright A.L., Holberg C., Martinez F.D., Taussig L.M., Relationship of parental smoking to wheezing and nonwheezing lower respiratory tract illness in infancy, J Pediatr, 118, pp. 207-214, (1991)

[6]

Goren A.I., Hellmann S., Prevalence of respiratory symptoms and diseases in schoolchildren living in a polluted and in a low polluted area in Israel, Environ Res, 45, pp. 28-37, (1988)

[7]

Neas L.M., Dockery D.W., Ware J.H., Spengler J.D., Speizer F.E., Ferris B.G., Association of indoor nitrogen dioxide with respiratory symptoms and pulmonary function in children, Am J Epidemiol, 134, pp. 204-219, (1991)

[8]

Gergen P., Mullally D., Evans R., National survey of prevalence of asthma among children in the United States, 1976 to 1988, Pediatrics, 81, pp. 1-7, (1988)

[9]

Burney P., Chinn S., Rona R.J., Has the prevalence of asthmaincreased in children? Evidence from the National Study of Health and Growth 1973-1986, Br Med J, 300, pp. 1306-1310, (1990)

[10]

Robertson C.F., Heycook E., Bishop J., Nolan T., Olinsky A., Phelan P.D., Prevalence of asthma in Melbourne schoolchildren: Changes over 26 years, Br Med J, 302, pp. 1116-1118, (1991)

← 1 2 3 4 5 →