ON MECHANISMS OF TRANSPORT AND BIOLOGICAL SIGNIFICANCE OF ANTIBODIES IN EXTERNAL SECRETIONS

被引：13

作者：

TOMASI, TB

机构：

[1] Rheumatic Disease Unit, Department of Medicine, State University of New York at Buffalo, Buffalo, New York

来源：

ARTHRITIS AND RHEUMATISM | 1969年 / 12卷 / 01期

关键词：

D O I：

10.1002/art.1780120108

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent evidence suggests that the antibodies present in certain external secretions are produced locally, and that the predominant immunoglobulin in these secretions appears to be γA, which is complexed to a nonimmunoglobulin glycoprotein referred to as the secretory “piece” or T chain. The secretory immunoglobulin system may be of importance in determining local flora and the resistance of mucous membranes to colonization by potentially pathogenic bacteria and viruses, and may be involved in hypersensitivity reactions on mucous surfaces as well as in certain so‐called autoimmune processes. Copyright © 1969 American College of Rheumatology

引用

页码：45 / &

共 29 条

[1]

ACKERMAN GA, 1964, THYMUS IMMUNOBIOLOGY, P123

[2]

ADINOLFI M, 1966, IMMUNOLOGY, V10, P517

[3]

ARBESMAN CE, 1968, 6 P INT C ALL MONTR

[4] COLOSTRAL IMMUNOGLOBULIN-A - SYNTHESIS IN VITRO OF T-CHAIN BY RABBIT MAMMARY GLAND [J].