CHANGES IN THE EXPRESSION OF ELASTASE AND CATHEPSIN-B WITH DIFFERENTIATION OF U937 PROMONOCYTES BY GMCSF

被引：24

作者：

WARD, CJ

CROCKER, J

CHAN, SJ

STOCKLEY, RA

BURNETT, D

机构：

[1] GEN HOSP,CLIN TEACHING BLOCK,BIRMINGHAM B4 6NH,W MIDLANDS,ENGLAND

[2] E BIRMINGHAM DIST GEN HOSP,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

[3] UNIV BIRMINGHAM,DEPT IMMUNOL,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[4] UNIV BIRMINGHAM,DEPT MED,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

[5] UNIV CHICAGO,HOWARD HUGHES MED INST,CHICAGO,IL 60637

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 167卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)92076-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human promonocytic cell line, U937, when treated for up to 72h with 12,0,tetradecanoyl-phorbol-13-acetate or granulocyte-macrophage colony-stimulating factor, exhibited increased phagocytic activity and expression of the marker p150 95. There was an associated increase in the monocyte proteinase cathepsin B and its mRNA but decreased cellular levels of neutrophil elastase and elastase mRNA. Granulocyte-macrophage colony-stimulating factor therefore causes differentiation of U937 cells, with appropriate effects on the synthesis of leukocyte proteinases. © 1990.

引用

页码：659 / 664

页数：6

共 22 条

[1] CATHEPSIN-B SYNTHESIS BY THE HL60 PROMYELOCYTIC CELL-LINE - EFFECTS OF STIMULATING AGENTS AND ANTIINFLAMMATORY COMPOUNDS [J].