1,2,3-TRIAZOLO[5,1-B]THIAZOLES .2. LITHIATION EXPERIMENTS LEADING TO 2,4-DISUBSTITUTED THIAZOLES

被引：10

作者：

JONES, G ^{[1
]}

OLLIVIERRE, H ^{[1
]}

FULLER, LS ^{[1
]}

YOUNG, JH ^{[1
]}

机构：

[1] SHELL SYNTHET CHEM LTD,WOLVERHAMPTON WV10 7BP,ENGLAND

来源：

TETRAHEDRON | 1991年 / 47卷 / 16-17期

关键词：

D O I：

10.1016/S0040-4020(01)87091-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Methyltriazolothiazole (2) and 3-phenyltriazolothiazole (3) were regiospecifically lithiated at position 6, triazolothiazole (1) at position 6 and 3 with the former predominating. The lithiated triazolothiazoles (4), (10) and (11) reacted with a number of electrophiles to give x:6-disubstituted triazolothiazoles, which could be converted into 2,4-disubstituted thiazoles.

引用

页码：2861 / 2870

页数：10