HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC DETERMINATION OF PROPYLTHIOURACIL IN HUMAN-PLASMA

被引：18

作者：

RINGHAND, HP ^{[1
]}

RITSCHEL, WA ^{[1
]}

机构：

[1] UNIV CINCINNATI,COLL PHARM,CINCINNATI,OH 45267

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 11期

关键词：

High‐pressure liquid chromatography—analysis; propylthiouracil; human plasma; Propylthiouracil—analysis; high‐pressure liquid chromatography; Thyroid inhibitors—propylthiouracil; high‐pressure liquid chromatographic analysis;

D O I：

10.1002/jps.2600681136

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A high‐pressure liquid chromatographic procedure was developed for the determination of propylthlouracil in plasma. The method utilizes a reversed‐phase C18 chromatographic column and UV detection at 280 nm. The method is sufficiently sensitive for most bioavailability and pharmacokinetic studies. Concentrations between 0.1 and 5.0 μg/ml were measured with a coefficient of variation of 0.6‐5.3% for a given day. Methylthiouracil was employed as an internal standard. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1461 / 1463

页数：3

共 15 条

[1] METABOLISM OF 35S-LABELLED ANTITHYROID DRUGS IN MAN [J].

ALEXANDER, WD ;

EVANS, V ;

MACAULAY, A ;

GALLAGHER, TF ;

LONDONO, J .

BMJ-BRITISH MEDICAL JOURNAL, 1969, 2 (5652) :290-+

[2] ACTION AND KINETICS OF PROPYLTHIOURACIL [J].

DESBARAT.ML ;

SCHONBAUM, E ;

SELLERS, EA ;

KOVES, E ;

ENDRENYI, L .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1972, 19 (01) :104-+

[3] VAPOR-PHASE SILYLATION OF LABORATORY GLASSWARE [J].

FENIMORE, DC ;

DAVIS, CM ;

WHITFORD, JH ;

HARRINGTON, CA .

ANALYTICAL CHEMISTRY, 1976, 48 (14) :2289-2290

[4] EXCRETION OF PROPYLTHIOURACIL AND ITS METABOLITES IN RAT BILE AND URINE [J].

LINDSAY, RH ;

HILL, JB ;

KELLY, K ;

VAUGHN, A .

ENDOCRINOLOGY, 1974, 94 (06) :1689-1698

[5]

LINDSAY RH, 1978, ALA J MED SCI, V15, P149

[6]

MACGEE J, 1972, P WORKSHOP DETERMINA

[7] CONCENTRATION OF S-35-PROPYLTHIOURACIL BY THYROID GLAND AND ITS RELATIONSHIP TO ANION TRAPPING MECHANISM [J].

MARCHANT, B ;

ALEXANDER, WD ;

ROBERTSON, JW ;

LAZARUS, JH .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1971, 20 (11) :989-+

[8]

MCGINTY DA, 1950, J CLIN ENDOCRINOL, V8, P1043

[9]

MELANDER A, 1977, ACTA MED SCAND, V201, P41

[10]

MEYER MC, 1978, FDA223773011 DHEWPHS

← 1 2 →