SYNAPTOPHYSIN EXPRESSION IN THE STRIATUM IN HUNTINGTONS-DISEASE

被引：32

作者：

GOTO, S ^{[1
]}

HIRANO, A ^{[1
]}

机构：

[1] MONTEFIORE MED CTR,DIV NEUROPATHOL,BLUESTONE LAB,III E 210TH ST,BRONX,NY 10467

来源：

ACTA NEUROPATHOLOGICA | 1990年 / 80卷 / 01期

关键词：

Calcineurin; Huntington's disease; Immunohistochemistry; Striatum; Synaptophysin;

D O I：

10.1007/BF00294227

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This immunohistochemical study compares the expression of synaptophysin (SYP) in the striatum in Huntington's disease (HD) with that of calcineurin (CaN), a marker for striatal medium-sized spinous neurons. As compared to controls, in the HD striatum there was a significant loss of SYP immunoreactivity with residual staining displaying an inhomogeneous pattern, which strikingly resembled that of CaN. Our results may indicate that there is a synaptic loss in the striatum with HD and this is most likely due to loss of medium-sized spinous neurons characteristic of this disease. © 1990 Springer-Verlag.

引用

页码：88 / 91

页数：4

共 16 条

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