INFLUENCE OF HYDROPHOBICITY ON OLIGOPEPTIDE UTILIZATION BY ORAL STREPTOCOCCI

被引:12
作者
COWMAN, RA [1 ]
BARON, SS [1 ]
机构
[1] UNIV MIAMI,SCH MED,DEPT MED,MIAMI,FL 33152
关键词
D O I
10.1177/00220345900690121101
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The growth responses of Streptococcus mutans VA-29R, Streptococcus sanguis ATCC 10556, and Streptococcus mitior NIH to hydrophilic and hydrophobic peptides obtained following isopropanol fractionation of Trypticase were compared. Although the two fractions contained peptides of similar molecular size, differences were observed with respect to amino acid compositions. S. mutans VA-29R showed a pronounced difference in growth response to hydrophilic vs. hydrophobic peptides. While growth of this micro-organism on hydrophilic peptides was indistinguishable from that on unfractionated Trypticase, only very slow growth occurred on the hydrophobic peptides. S. sanguis ATCC 10556 and S. mitior NIH also displayed some selectivity, as evidenced by their faster relative growth rates on hydrophilic, as compared with hydrophobic, peptides. The results of this study support the conclusion that the properties of the substrate, as defined by its amino acid composition, may be more important than molecular size as a factor influencing recognition and subsequent utilization of oligopeptides as sources of amino acids for growth by these three oral streptococci. © 1990, SAGE Publications. All rights reserved.
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页码:1847 / 1851
页数:5
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